S100 proteins in cancer

Role of S100 Proteins in Colorectal Carcinogenesis

The family of S100 proteins represents 25 relatively small (9-13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after lung and prostate cancer) and the second most frequent cancer in women (after breast cancer) worldwide. S100 proteins are involved in the colo...

S100 Calcium Binding Proteins and Ion Channels

S100 Ca(2+)-binding proteins have been associated with a multitude of intracellular Ca(2+)-dependent functions including regulation of the cell cycle, cell differentiation, cell motility and apoptosis, modulation of membrane-cytoskeletal interactions, transduction of intracellular Ca(2+) signals, and in mediating learning and memory. S100 proteins are fine tuned to read the intracellular free C...

S100 protein family in human cancer.

S100 protein family has been implicated in multiple stages of tumorigenesis and progression. Among the S100 genes, 22 are clustered at chromosome locus 1q21, a region frequently rearranged in cancers. S100 protein possesses a wide range of intracellular and extracellular functions such as regulation of calcium homeostasis, cell proliferation, apoptosis, cell invasion and motility, cytoskeleton ...

S100 proteins in the pathogenesis of Kawasaki disease.

The Roles of S100 Proteins and RAGE in Melanoma

The incidence of melanoma continues to rise worldwide and increases annually by 4% to 6% in the United States (Darrell and Rigel 2010). Once metastatic, invasive melanoma offers poor prognosis to patients (Bhatia, Tykodi and Thompson, 2009). The classic prognostic factors in melanoma include primary tumor thickness, patient gender, primary melanoma ulceration, mitotic activity and the presence ...